Biphosponates such as Boniva, Fosamax, Actonel, etc, as a class has new alert issued by FDA.
This class of drugs have possibility of causing severe musculo-skeletal pain starting within days, month or even years after initiation of treatment.
It is different from acute state response.
Symptoms are fever, chills, bone pain, muscle pain, joint pain.
In some cases patients reported complete relief of symptoms, in others slow and incomplete resolution.


Vitamin D deficiency may increase the risk of cardiovascular disease especially in people with high blood pressure ( Framingham offspring study). Forthermore the higher risk appear to increase as VItamin D levels decline.

Alcohol dependent persons with cirrhosis of the liver, who were treated with Baclophen , a GABA receptor agonist, were more than 6 times likely to stop alcohol use then placebo group.
This is particularly important finding, because patients with cirrhosis are usually excluded from studies of anticraving drugs because of concern of further liver damage.