Antidepressant Paxil appears to put healthy men at increased risk of DNA damage that may result in adverse reproductive outcomes.
" Healthy volunteers demonstrated a dramatic increase in DNA fragmentation within just a few weeks of paroxetine treatment, wihtout an apparrent impact on standard semen parameters. "
Certainly one should query male patients about SSRI use.
However it would be premature to suggest a patient come off SSRI's altogether or change to alternate therapy given the lack of data regarding other newer antidepressants"
Paxil was given for 5 weeks and semen analysis were performed at week 2 and 4.
One month after cessation of therapy final semen analysis was performed.
The unadjusted odds ratio of having abnormal DNA fragmentation on Paxil was 9.33
In addition up to 35% of men noted significant changes in erectile function and up to 47% reported ejaculatory difficulties while on Paxil.
At least partial recovery of sexual function was noted within 1 month of stopping treatment.
The study was supported by the Frederick J. and Theresa Dow Wallace Fund of the New York Community Trust and Brady Urology Foundation.
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